研究業績

 

  1. Sakata T, Yoshio S, Yamazoe T, Mori T, Kakazu E, Aoki Y, Aoyanagi N, Okamoto T, Ito T, Toyoda H, Kawaguchi T, Ono Y, Takahashi Y, Taketomi A, Kanto T.　Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma.  Front Immunol. 2024 Apr 4;15:1389411.
  2. Minami S, Kotaki T, Sakai Y, Okamura S, Torii S, Ono C, Motooka D, Hamajima R, Nouda R, Nurdin JA, Yamasaki M, Kanai Y, Ebina H, Maeda Y, Okamoto T, Tachibana T, Matsuura Y, Kobayashi T.Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage. Microbiol Spectr. 2024 Feb 28:e0285923.
  3. Fujimoto K, Kameda Y, Nagano Y, Deguchi S, Yamamoto T, Krol RP, Gee P, Matsumura Y, Okamoto T, Nagao M, Takayama K, Yokokawa R.SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids. Lab Chip. 2024 Jan 22. doi: 10.1039/d3lc00768e.
  4. Samune Y, Saito A, Sasaki T, Koketsu R, Srimark N, Phadungsombat J, Yokoyama M, Kotani O, Sato H, Yamanaka A, Haga S, Okamoto T, Kurosu T, Nakayama EE, Shioda T.Genetic regions affecting the replication and pathogenicity of dengue virus type 2.PLoS Negl Trop Dis. 2024 Jan 8;18(1):e0011885.
  5. Kawai A, Tokunoh N, Kawahara E, Tamiya S, Okamura S, Ono C, Anindita J, Tanaka H, Akita H, Yamasaki S, Kunisawa J, Okamoto T, Matsuura Y, Hirai T, Yoshioka Y.Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses. J Clin Invest. 2023 Dec 1;133(23):e166827.
  6. Okabe J, Kodama T, Sato Y, Shigeno S, Matsumae T, Daiku K, Sato K, Yoshioka T, Shigekawa M, Higashiguchi M, Kobayashi S, Hikita H, Tatsumi T, Okamoto T, Satoh T, Eguchi H, Akira S, Takehara T.Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity.J Exp Clin Cancer Res. 2023 Oct 9;42(1):262.
  7. Tokunoh N, Tamiya S, Watanabe M, Okamoto T, Anindita J, Tanaka H, Ono C, Hirai T, Akita H, Matsuura Y, Yoshioka Y.A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice .Front Immunol.2023 Aug 31;14:1224634.
  8. Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T.An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.Sci Transl Med. 2023 Aug 30;15(711):eadi2623.
  9. Minami S, Matsumoto N, Omori H, Nakamura Y, Tamiya S, Nouda R, Nurdin JA, Yamasaki M, Kotaki T, Kanai Y, Okamoto T, Tachibana T, Ushijima H, Kobayashi T, Sato S.Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells.Sci Rep. 2023 Jul 18;13(1):11610.
  10. Mitsui Y, Suzuki T, Kuniyoshi K, Inamo J, Yamaguchi K, Komuro M, Watanabe J, Edamoto M, Li S, Kouno T, Oba S, Hosoya T, Masuhiro K, Naito Y, Koyama S, Sakaguchi N, Standley DM, Shin JW, Akira S, Yasuda S, Miyazaki Y, Kochi Y, Kumanogoh A, Okamoto T, Satoh T.Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity.Immunity. 2023 Aug 8;56(8):1939-1954.
  11. Katahira J, Ohmae T, Yasugi M, Sasaki R, Itoh Y, Kohda T, Hieda M, Yokota Hirai M, Okamoto T, Miyamoto Y.Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex.Nucleic Acids Res. 2023 Aug 11;51(14):7602-7618.
  12. Havranek B, Lindsey GW, Higuchi Y, Itoh Y, Suzuki T, Okamoto T, Hoshino A, Procko E, Islam SM. A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo. Commun Biol. 2023 May 12;6(1):513.
  13. Muranaka M, Takamatsu S, Ouchida T, Kanazawa Y, Kondo J, Nakagawa T, Egashira Y, Fukagawa K, Gu J, Okamoto T, Kamada Y, Miyoshi E. Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells. Int J Mol Sci. 2023 Apr 11;24(8):7037.
  14. Uchida T, Imamura M, Hayes CN, Suehiro Y, Teraoka Y, Ohya K, Aikata H, Abe-Chayama H, Ishida Y, Tateno C, Hara Y, Hino K, Okamoto T, Matsuura Y, Aizaki H, Wake K, Kohara M, Liang TJ, Oka S, Chayama K. HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice. Hepatology. 2023 Sep 1;78(3):929-942.
  15. Inoue T, Shinnakasu R, Kawai C, Yamamoto H, Sakakibara S, Ono C, Itoh Y, Terooatea T, Yamashita K, Okamoto T, Hashii N, Ishii-Watabe A, Butler NS, Matsuura Y, Matsumoto H, Otsuka S, Hiraoka K, Teshima T, Murakami M, Kurosaki T. Antibody feedback contributes to facilitating the development of Omicron- reactive memory B cells in SARS-CoV-2 mRNA vaccinees. J Exp Med. 2023 Feb 6;220(2):e20221786.
  16. Arai Y, Yamanaka I, Okamoto T (Co-first), Isobe A, Nakai N, Kamimura N, Suzuki T, Daidoji T, Ono T, Nakaya T, Matsumoto K, Okuzaki D, Watanabe Y. Stimulation of IFN-β responses by aberrant SARS-CoV-2 small viral RNAs acting as RIG-I agonists. iScience. 2022 Dec 7:105742.
  17. Hashizume M, Takashima A, Ono C, Okamoto T, Iwasaki M. Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1. Antiviral Res. 2022 Dec 5;209:105481.
  18. Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M. Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry. mBio. 2022 Nov 8:e0169822.
  19. Kohyama M, Suzuki T, Nakai W, Ono C, Matsuoka S, Iwatani K, Liu Y, Sakai Y, Nakagawa A, Tomii K, Ohmura K, Okada M, Matsuura Y, Ohshima S, Maeda Y, Okamoto T (corresponding author), Arase H. SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses. Int Immunol. 2022 Sep 2:dxac044.
  20. Arimori T, Ikemura N, Okamoto T, Takagi J, Standley DM, Hoshino A. Engineering ACE2 decoy receptors to combat viral escapability. Trends Pharmacol Sci. 2022 Oct;43(10):838-851.
  21. Sano E, Suzuki T, Hashimoto R, Itoh Y, Sakamoto A, Sakai Y, Saito A, Okuzaki D, Motooka D, Muramoto Y, Noda T, Takasaki T, Sakuragi JI, Minami S, Kobayashi T, Yamamoto T, Matsumura Y, Nagao M, Okamoto T (corresponding author), Takayama K. Cell response analysis in SARS-CoV-2 infected bronchial organoids. Commun Biol. 2022 May 30;5(1):516.
  22. Miyamoto Y, Itoh Y, Suzuki T, Tanaka T, Sakai Y, Koido M, Hata C, Wang CX, Otani M, Moriishi K, Tachibana T, Kamatani Y, Yoneda Y, Okamoto T (corresponding author), Oka M. SARS- CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication. Commun Biol. 2022 May 19;5(1):483.
  23. Nakayama EE, Kubota-Koketsu R, Sasaki T, Suzuki K, Uno K, Shimizu J, Okamoto T, Matsumoto H, Matsuura H, Hashimoto S, Tanaka T, Harada H, Tomita M, Kaneko M, Yoshizaki K, Shioda T. Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein. Sci Rep. 2022 May 16;12(1):8108.
  24. Ikemura N, Taminishi S, Inaba T, Arimori T, Motooka D, Katoh K, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T (corresponding author), Takagi J, Hoshino A. An engineered ACE2 decoy neutralizes the SARS- CoV-2 Omicron variant and confers protection against infection in vivo. Sci Transl Med. 2022 Jun 22;14(650).
  25. Tanaka T, Saito A, Suzuki T, Miyamoto Y, Takayama K, Okamoto T, Moriishi K. Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening. Antiviral Res. 2022 199:105268.
  26. Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, Hara E. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response, Nature Aging. 2022 2:115-124.
  27. Zhang H, Itoh Y, Suzuki T, Ihara KI, Tanaka T, Haga S, Enatsu H, Yumiya M, Kimura M, Takada A, Itoh D, Shibazaki Y, Nakao S, Yoshio S, Miyakawa K, Miyamoto Y, Sasaki H, Kajita T, Sugiyama M, Mizokami M, Tachibana T, Ryo A, Moriishi K, Miyoshi E, Kanto T, Okamoto T (corresponding author), Matsuura Y. Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus. Microbiol Immunol. 2022 Apr;66(4):179-192.
  28. Saito A, Shofa M, Ode H, Yumiya M, Hirano J, Okamoto T (corresponding author), Yoshimura SH. How Do Flaviviruses Hijack Host Cell Functions by Phase Separation? Viruses. 2021 Jul 28;13(8):1479.
  29. Deguchi S, Shintani T, Harada K, Okamoto T, Takemura A, Hirata K, Ito K, Takayama K, Mizuguchi H. In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology. Hepatol Commun. 2021 May 5;5(8):1385-1399.
  30. Yoshida Y, Yoshio S, Yamazoe T, Mori T, Tsustui Y, Kawai H, Yoshikawa S, Fukuhara T, Okamoto T, Ono Y, Takahashi Y, Hashida R, Kawaguchi T, Taketomi A, Kanto T. Phenotypic Characterization by Single-Cell Mass Cytometry of Human Intrahepatic and Peripheral NK Cells in Patients with Hepatocellular Carcinoma. Cells. 2021 Jun 14;10(6):1495.
  31. Higuchi Y, Suzuki T, Arimori T, Ikemura N, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T (corresponding author), Takagi J, Hoshino A. Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2. Nat Commun. 2021 Jun 21;12(1):3802.
  32. Liu Y, Soh WT, Kishikawa JI, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H. An infectivity- enhancing site on the SARS-CoV-2 spike protein targeted by antibodies. Cell. 2021 Jun 24;184(13):3452-3466.e18.
  33. Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T (corresponding author). Hepatitis C virus modulates signal peptide peptidase to alter host protein processing. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2026184118.
  34. Joshita S, Yamashita Y, Okamoto T, Usami Y, Sugiura A, Yamazaki T, Kakino A, Ota M, Sawamura T, Umemura T. Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct-acting antivirals. Hepatol Res. 2021 Jul;51(7):758-766.
  35. Roy MJ, Vom A, Okamoto T, Smith BJ, Birkinshaw RW, Yang H, Abdo H, White CA, Segal D, Huang DCS, Baell JB, Colman PM, Czabotar PE, Lessene G. Structure- Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2. J Med Chem. 2021 May 13;64(9):5447-5469.
  36. Nakae A, Kodama M, Okamoto T, Tokunaga M, Shimura H, Hashimoto K, Sawada K, Kodama T, Copeland NG, Jenkins NA, Kimura T. Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl- diphosphate farnesyltransferase 1. Biochem Biophys Res Commun. 2021 May 7;552:120-127.
  37. Chen DV, Suzuki T, Itoh Y, Maeda Y, Hirano J, Haga S, Zhang H, Ito D, Matsuura Y, Okamoto T (corresponding author). Deneddylation by SENP8 restricts hepatitis B virus propagation. Microbiol Immunol. 2021 Mar;65(3):125-135.
  38. Fauzyah Y, Ono C, Torii S, Anzai I, Suzuki R, Izumi T, Morioka Y, Maeda Y, Okamoto T, Fukuhara T, Matsuura Y. Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation. Antiviral Res. 2021 Feb;186:104999.
  39. Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, Yoshio S, Li S, Nojima S, Motooka D, Nakamura S, Kida H, Standley DM, Morii E, Kanto T, Yanagita M, Matsuura Y, Nagasawa T, Kumanogoh A, Akira S. Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 2020 Mar 17;52(3):542-556.e13.
  40. Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. Cell Death Differ. 2020 Aug;27(8):2484-2499.
  41. Tokunaga M, Miyamoto Y, Suzuki T, Otani M, Inuki S, Esaki T, Nagao C, Mizuguchi K, Ohno H, Yoneda Y, Okamoto T (corresponding author), Oka M, Matsuura Y. Novel anti- flavivirus drugs targeting the nucleolar distribution of core protein. Virology. 2020 Feb;541:41-51.
  42. Tamura T, Igarashi M, Enkhbold B, Suzuki T, Okamatsu M, Ono C, Mori H, Izumi T, Sato A, Fauzyah Y, Okamoto T, Sakoda Y, Fukuhara T, Matsuura Y. In Vivo Dynamics of Reporter Flaviviridae Viruses. J Virol. 2019 Oct 29;93(22):e01191-19.
  43. Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M. CXCR4 regulates Plasmodium development in mouse and human hepatocytes. J Exp Med. 2019 Aug 5;216(8):1733-1748.
  44. Mano Y, Yoshio S, Shoji H, Tomonari S, Aoki Y, Aoyanagi N, Okamoto T, Matsuura Y, Osawa Y, Kimura K, Yugawa K, Wang H, Oda Y, Yoshizumi T, Maehara Y, Kanto T. Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma. J Gastroenterol. 2019 Nov;54(11):1007-1018.
  45. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T (corresponding author), Matsuura Y. USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation. J Virol. 2019 Mar 5;93(6):e01708-18.
  46. Deng L, Gan X, Ito M, Chen M, Aly HH, Matsui C, Abe T, Watashi K, Wakita T, Suzuki T, Okamoto T, Matsuura Y, Mizokami M, Shoji I, Hotta H. Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA. J Virol. 2019 Mar 5;93(6):e02203-18.
  47. Mori H, Fukuhara T, Ono C, Tamura T, Sato A, Fauzyah Y, Wada M, Okamoto T, Noda T, Yoshimori T, Matsuura Y. Induction of selective autophagy in cells replicating hepatitis C virus genome. J Gen Virol. 2018 Dec;99(12):1643-1657.
  48. Suzuki T, Okamoto T (corresponding author), Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y. Infection with flaviviruses requires BCLXL for cell survival. PLoS Pathog. 2018 Sep 27;14(9):e1007299.
  49. Ono C, Okamoto T, Abe T, Matsuura Y. Baculovirus as a Tool for Gene Delivery and Gene Therapy. Viruses. 2018 Sep 19;10(9):510.
  50. Priyambada SA, Misaki R, Okamoto T, Ohashi T, Ueda K, Matsuura Y, Fujiyama K. St6gal1 knockdown alters HBV life cycle in HepAD38 cells. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1841-1847.
  51. Oka H, Masuno K, Uehara T, Okamoto T, Matsuura Y, Nakano T, Yamaguchi S. Novel miRNA biomarkers for genotoxicity screening in mouse. Toxicology. 2018 Jul 1;404-405:68-75.
  52. Ono C, Hirano J, Okamoto T, Matsuura Y. Evaluation of viral contamination in a baculovirus expression system. Microbiol Immunol. 2018 Mar;62(3):200-204.
  53. Hirano J, Okamoto T (corresponding author), Sugiyama Y, Suzuki T, Kusakabe S, Tokunaga M, Fukuhara T, Sasai M, Tougan T, Matsunaga Y, Yamashita K, Sakai Y, Yamamoto M, Horii T, Standley DM, Moriishi K, Moriya K, Koike K, Matsuura Y. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10782-E10791.
  54. Tamura T, Fukuhara T, Uchida T, Ono C, Mori H, Sato A, Fauzyah Y, Okamoto T, Kurosu T, Setoh YX, Imamura M, Tautz N, Sakoda Y, Khromykh AA, Chayama K, Matsuura Y. Characterization of Recombinant Flaviviridae Viruses Possessing a Small Reporter Tag. J Virol. 2018 Jan 2;92(2). pii: e01582-17.
  55. Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase. Cell Rep. 2017 Oct 3;21(1):259-273.
  56. Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T. The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses. Cell Rep. 2017 Sep 19;20(12):2944-2954.
  57. Okamoto T, Suzuki T, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Matsuura Y. Regulation of apoptosis during Flavivirus infection. Viruses. 2017 Aug 28;9(9):243.
  58. Kurihara T, Fukuhara T, Ono C, Yamamoto S, Uemura K, Okamoto T, Sugiyama M, Motooka D, Nakamura S, Ikawa M, Mzokami M, Maehara Y, Matsuura Y. Suppression of HBV replication by the expression of nickase- and nuclease dead Cas9. Sci Rep 2017 Jul 21;7(1):6122.
  59. Priyambada SA, Misaki R, Okamoto T, Okamoto Y, Ohashi T, Ueda K, Matsuura Y, Fujiyama K. Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus. Virus Res. 2017 Jun 15;238:101-109.
  60. Fukuhara T, Tamura T, Ono C, Shiokawa M, Mori H, Uemura K, Yamamoto S, Kurihara T, Okamoto T, Suzuki R, Yoshii K, Kurosu T, Igarashi M, Aoki H, Sakoda Y, Matsuura Y. Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae. Plos Pathog. 2017 Jun 23;13(6):e1006475.
  61. Ono C, Fukuhara, T, Motooka D, Nakamura S, Okuzaki D, Yamamoto S, Tamura T, Mori H, Sato A, Uemura K, Fauzyah Y, Kurihara T, Suda T, Nishio A, Hmwe SS, Okamoto T, Tatsumi T, Takehara T, Chayama K, Wakita T, Koike K, Matsuura Y. Characterization of miR-122-independent propagation of HCV. PLoS Pathog. 2017 May 11;13(5):e1006374.
  62. Fukuhara T, Yamamoto S, Ono C, Nakamura S, Motooka D, Mori H, Kurihara T, Sato A, Tamura T, Motomura T, Okamoto T, Imamura M, Ikegami T, Yoshizumi T, Soejima Y, Maehara Y, Chayama K, Matsuura Y.  Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivi. Sci Rep. 2017 Mar 22;7:45228.
  63. Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K,  Fujimoto T, Sakurai T, Kurebayashi N. Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity. J Gen Physiol. 2017 Feb;149(2):199-218.
  64. Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K. Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Antiviral Res. 2016 Sep;133:156-64. 
  65. Puig-Basagoiti F, Fukuhara T, Tamura T, Ono C, Uemura K, Kawachi Y, Yamamoto S, Mori H, Kurihara T, Okamoto T, Aizaki H, Matsuura Y. Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation. J Virol. 2016 Sep 12;90(19):8464-77.
  66. Yamamoto S, Fukuhara T, Ono C, Uemura K, Kawachi Y, Shiokawa M, Mori H, Wada M, Shima R, Okamoto T, Hiraga N, Suzuki R, Chayama K, Wakita T, Matsuura Y. Lipoprotein receptors redundantly participate in entry of hepatitis C virus. PLoS Pathog. 2016 May 6;12(5):e1005610.
  67. Aizawa S, Okamoto T (Co-first), Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga, M, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, Matsuura Y. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Nat Commun. 2016 May 4;7:11379.
  68. Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman NN, Hanieh H, Higa M, Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T, Matsuura Y, Takeuchi O, Kishimoto T. Arid5a regulates naïve CD4+ T-cell fate through selective stabilization of Stat3 mRNA. J Exp Med. 2016 Apr 4;213(4):605-19.
  69. Shima R, Li TC, Sendai Y, Kataoka C, Mori Y, Abe T, Takeda N, Okamoto T, Matsuura Y. Production of hepatitis E virus-like particles presenting multiple foreign epitopes by co-infection of recombinant baculoviruses. Sci Rep. 2016 Feb 24;6:21638. 
  70. Kouwaki T, Okamoto T (Co-first), Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y. Hepatocyte factor JMJD5 regulates HBV replication through interaction with HBx. J virol.2016 Jan 20;90(7):3530-42.
  71. Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T. Indoleamine-2, 3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B. Hepatology 2016 Jan;63(1):83-94.
  72. Dobashi-Okuyama K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K. Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. Sci Rep. 2015 Nov 23;5:17047.
  73. Kasai K, Kawakami K, Yokoe H, Yoshimura K, Matsuda M, Yasumoto J, Maekawa S, Yamashita A, Tanaka T, Ikeda M, Kato N, Okamoto T, Matsuura Y, Sakamoto N, Enomoto N, Takeda S, Fujii H, Tsubuki M, Kusunoki M, Moriishi K. Involvement of FKBP6 in hepatitis C virus replication. Sci Rep. 2015 Nov 16;5:16699. 
  74. Matsuhisa K, Yamane S, Okamoto T, Watari A, Kondoh M, Matsuura Y, Yagi K. Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin. Biochem Biophys Res Commun. 2015 Jun 19;462(1):52-7.
  75. Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y. Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles. PLoS Pathog. 2014 Dec 11;10(12):e1004534.
  76. Tanaka T, Kasai H, Yamashita A, Okuyama-Dobashi K, Yasumoto J, Maekawa S, Enomoto N, Okamoto T, Matsuura Y, Morimatsu M, Manabe N, Ochiai K, Yamashita K, Moriishi K. Hallmarks of hepatitis C virus in equine hepacivirus. J Virol. 2014 Nov;88(22):13352-66.
  77. Shiokawa M, Fukuhara T, Ono C, Yamamoto S, Okamoto T, Watanabe N, Wakita T, Matsuura Y. Novel permissive cell lines for complete propagation of hepatitis C virus. J Virol. 2014 May;88(10):5578-94.
  78. Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. Further insights into the effects of pre-organizing the BimBH3 helix. ACS Chem Biol. 2014 Mar 21;9(3):838-9. 
  79. Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DCS, Bouillet P, Rowe M, Rickinson AB, Herold MJ and Strasser A. Targetting of MCL-1 kills MYC-driven mouse and human lymphomas eve when they bear mutations in p53. Genes Dev. 2014 Jan 1;28(1):58-70.
  80. Okamoto T, Coultas L, Metcalf D, van Delft M, Glasser SP, Takiguchi M, Strasser A, Bouillet P,  Adams JM, Hunag DCS. Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunt stress-induced apoptosis, causes male sterility, and promotes tumorigenesis. Proc Natl Acad Sci USA 2014 Jan 7;111(1):261-6.
  81. Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y. Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells. J Virol. 2014 Feb;88(4):2157-67.
  82. Brumatti G, Salmanidis M, Kok CH, Bilardi RA, Sandow JJ, Silke N, Mason K, Visser J, Jabbour AM, Glaser SP, Okamoto T, Bouillet P, D'Andrea RJ, Ekert PG. HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia. Oncotarget. 2013 Nov;4(11):1933-47.
  83. Salmanidis M, Brumatti G, Narayan N, Green BD, van den Bergen JA, Sandow JJ, Bert AG, Silke N, Sladic R, Puthalakath H, Rohrbeck L, Okamoto T, Bouillet P, Herold MJ, Goodall GJ, Jabbour AM, Ekert PG. Hoxb8 regulates expression of microRNAs to control cell death and differentiation. Cell Death Differ.2013 Oct;20(10):1370-80.
  84. Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism. Immunity. 2013 Sep 19;39(3):443-53.
  85. Kimura T, Katoh H, Kayama H, Saiga H, Okuyama M, Okamoto T, Umemoto E, Matsuura Y, Yamamoto M, Takeda K. Ifit1 inhibits JEV replication through binding to 5' capped 2'-O unmethylated RNA. J Virol. 2013 Sep;87(18):9997-10003.  
  86. Tripathi LP, Kambara H, Chen YA, Nishimura Y, Moriishi K, Okamoto T, Morita E, Abe T, Mori Y, Matsuura Y, Mizuguchi K. Understanding the Biological Context of NS5A-Host Interactions in HCV Infection: A Network-Based Approach. J Proteome Res. 2013 Jun 7;12(6):2537-51.
  87. Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity. ACS Chem Biol. 2013 Feb 15;8(2):297-302.
  88. Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death Dis. 2013 Jan 17;4:e465.
  89. Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y. Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation. J Virol. 2013 Jan;87(1):489-502.
  90. Giam M, Okamoto T, Mintern JD, Strasser A, Bouillet P. Bcl-2 family member Bcl-G is not a proapoptotic protein. Cell Death Dis. 2012 Oct 11;3:e404.
  91. Okamoto T, Campbell S, Mehta N, Thibault J, Colman PM, Barry M, Huang DC, Kvansakul M. Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins. J Virol. 2012 Nov;86(21):11501-11.
  92. Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DC, Soldati-Favre D, Horie K, Takeda J, Takeda K. A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity. 2012 Aug 24;37(2):302-13.
  93. Kajiura H, Okamoto T, Misaki R, Matsuura Y, Fujiyama K. Arabidopsis β1,2-xylosyltransferase:
    substrate specificity and participation in the plant-specific N-glycosylation pathway. J Biosci Bioeng. 2012 Jan;113(1):48-54.
  94. Yamamoto M, Chistina M, Ma JS, Saiga H, Kamiyama N, Kubo E, Okamoto T, Ito H, Okuyama M,
    Kayama H, Takashima S, Matsuura Y, Favre DS, Takeda K. ATF6β is a host cellular target of the
    Toxoplasma virulence factor ROP18. J Exp Med. 2011 Jul 4;208(7):1533-46.
  95. Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M,
    Liu J, Belmont LD, Kaminker J, O’Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR,
    Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJC, Leong KG, Dueber E, Maecker H, Huang DCS,
    Dixit VM. Sensitivity to Antitubulin Chemotherapeutics is Regulated by Mcl1 and FBW7. Nature 2011 Mar 3;471(7336):110-4.
  96. Banadyga L, Lam SC, Okamoto T, Kvansakul M, Huang DC, Barry M. Deerpox Virus Encodes an
    Inhibitor of Apoptosis that Regulates Bak and Bax. J Virol. 2011 Mar;85(5):1922-34.
  97. Kimura T, Imamura M, Hiraga N, Hatakeyama T, Miki D, Noguchi C, Mori N, Tsuge M, Takahashi S,
    Fujimoto Y, Iwao E, Ochi H, Abe H, Maekawa T, Arataki K, Tateno C, Yoshizato K, Wakita T,
    Okamoto T, Matsuura Y, Chayama K. Establishment of an infectious genotype 1b hepatitis C virus
    clone in human hepatocyte chimeric mice. J Gen Virol. 2008 Sep;89(Pt 9):2108-2113.
  98. Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K,
    Matsuura Y. Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane
    Localization of Hepatitis C Virus Core Protein and Viral Propagation. J Virol. 2008 Sep;82(17):8349-61.
  99. Okamoto T, Omori H, Kaname Y, Abe T, Nishimura Y, Suzuki T, Miyamura T, Yoshimori T, Moriishi K, Matsuura Y. A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication. J Virol. 2008 Apr;82(7):3480-9.
  100. Taguwa S, Okamoto T, Abe T, Mori Y, Suzuki T, Moriishi K, Matsuura Y. Human butyrate-induced
    transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication. J Virol. 2008 Mar;82(6):2631-41.
  101. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K,
    Ishii KJ, Takeuchi O, Kawai T, Akira S. Enhanced TLR-mediated NF-IL6–dependent, gene expression
    by Trib1 deficiency. J Exp Med. 2007 Sep 3;204(9):2233-9.
  102. Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, Moriishi K, Matsuura Y. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J. 2006 Oct 18;25(20):5015-25.
  103. Nakai K, Okamoto T, Kimura-Someya T, Ishii K, Lim CK, Tani H, Matsuo E, Abe T, Mori Y, Suzuki T, Miyamura T, Nunberg JH, Moriishi K, Matsuura Y. Oligomerization of Hepatitis C Virus Core Protein Is Crucial for Interaction with Cytoplasmic Domain of E1 Envelope Protein. J Virol. 2006 Nov;80(22):11265-73.
  104. Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S. Key function for Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol. 2006 Sep;7(9):962-70.
  105. Tsuda Y, Mori Y, Abe T, Yamashita T, Okamoto T, Ichimura T, Moriishi K, Matsuura Y. Nucleolar
    protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication. 
    Microbiol Immunol. 2006;50(3):225-34.
  106. Matsuo E, Tani H, Lim C, Komoda Y, Okamoto T, Miyamoto H, Moriishi K, Yagi S, Patel AH,
    Miyamura T, Matsuura Y. Characterization of HCV-like particles produced in a human hepatoma cell
    line by a recombinant baculovirus. Biochem Biophys Res Commun. 2006 Feb 3;340(1):200-8.
  107. Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, Abe T, Suzuki T, Lai MM,
    Miyamura T, Moriishi K, Matsuura Y. Human VAP-B is involved in HCV replication through the
    interaction with NS5A and NS5B. J Virol. 2005 Nov;79(21):13473-82.
  108. Okamoto T, Takagi M, Soma T, Ogawa H, Kawakami M, Mukubo M, Kubo K, Sato R, Toma K,
    Yoshida T. Effect of heparin addition on expansion of cord blood hematopoietic progenitor cells in
    three-dimensional coculture with stromal cells in nonwoven fabrics. J Artif Organs. 2004;7(4):194-202.